DIFFERENTIAL CONTRACTILE RESPONSE OF MIDDLE CEREBRAL ARTERY(MCA) TO HYPOTHERMIA DURING PERINATAL DEVELOPMENT. • 467
نویسندگان
چکیده
منابع مشابه
Moderate hypothermia to treat perinatal asphyxial encephalopathy.
BACKGROUND Whether hypothermic therapy improves neurodevelopmental outcomes in newborn infants with asphyxial encephalopathy is uncertain. METHODS We performed a randomized trial of infants who were less than 6 hours of age and had a gestational age of at least 36 weeks and perinatal asphyxial encephalopathy. We compared intensive care plus cooling of the body to 33.5 degrees C for 72 hours a...
متن کاملEffect of Combination Therapy Using Hypothermia and Granulocyte Colony-Stimulating Factor in a Rat Transient Middle Cerebral Artery Occlusion Model
Background: Stroke is the third leading cause of death. Hypothermia has been recognized as an effective method in reducing brain injury. In this study, we assessed the effects of granulocyte colony-stimulating factor (G-CSF) as a neuroprotective agent and mild hypothermia on mortality, behavioral function, infarct volume, and brain edema in Wistar rats. Methods: Forty male rats were used in fiv...
متن کاملCerebral blood flow and cerebral oxygen consumption during hypothermia.
C URRENTLY there is widespread interest in the physiologic effects of cold, and in the use of hypothermia with surgery (I, 2). Although no gross neurologic derangements have been observed following the application of this technique in man and experimental animals (3, 4), it seemed appropriate that a special study be made of the effects of hypothermia on cerebral physiology. Cerebral blood flow,...
متن کاملPerinatal cortical infarction within middle cerebral artery trunks.
AIM To define neonatal pial middle cerebral artery infarction. METHODS A retrospective study was made of neonates in whom focal arterial infarction had been detected ultrasonographically. A detailed study was made of cortical middle cerebral artery infarction subtypes. RESULTS Forty infarctions, with the exception of those in a posterior cerebral artery, were detected ultrasonographically o...
متن کاملSusceptibility of rat hippocampal neurons to hypothermia during development
PURPOSE This study evaluated the extent of damage due to hypothermia in the mature and immature brain. METHODS Hippocampal tissue cultures at 7 and 14 days in vitro (DIV) were used to represent the immature and mature brain, respectively. The cultures were exposed at 25℃ for 0, 10, 30, and 60 minutes (n=30 in each subgroup). Propidium iodide fluorescent images were captured 24 and 48 hours af...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-00487